Farmaco Nell’organismo infatti la mitomicina C viene ridotta nella forma diidrochinonica, che per successiva protonazione all’azoto aziridinico si trasforma in un agente bialchilante capace di legarsi, a livello del DNA, ai gruppi aminici dell’adenina e della citosina ed all’ossigeno della guanina (Tavola 6). Anche la ciclofosfamide...
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